Three Cases of Cutaneous Vascular Lesions,during the Anticancer Therapy with Ramucirumab

Abstract

We report three cases of cutaneous vascular lesions during anticancer therapy with combinations of ramucirumab and taxane chemotherapy. Case 1 was a 60-year-old man who developed a red nodule on the face. Case 2 was a 46-year-old woman who presented with a red nodule on the neck. Case 3 was a 58-year-old woman who had a fresh-red nodule on the right thumb. Histopathologically, all cases were diagnosed as pyogenic granuloma, and there was no withdrawal or dose-limitation of anticancer drug therapy. Ramucirumab is approved for diverse types of malignancy including nonsmall cell lung cancer, hepatocellular carcinoma, gastric cancer, and colorectal cancer. Dermatologists should be aware that even though there is an association between the cutaneous vascular lesions and ramucirumab, skin lesions can be managed by local procedures and the oncologist can maintain ramucirumab therapy. Skin Research, 21 : 314-320, 2022