Two Cases with Livedo Vasculopathy Improved by Switching from Edoxaban to Dabigatran

Abstract

Case 1 was a 35-year-old woman and Case 2 was a 25-year-old woman. Both patients had livedo reticularis and painful ulcers on the lower legs and dorsum of the foot. The patients were diagnosed as having livedo vasculopathy based on clinical ndings and histopathological examinations. Both patients were treated with anticoagulants, including edoxaban, antiplatelet agents, and vasodilators,and their symptoms improved. However, both of their conditions relapsed ; therefore, we replaced edoxaban with dabigatran, which resulted in a signicant improvement. Recent studies on the effectiveness of direct oral anticoagulants (DOACs) for livedo vasculopathy have yielded mixed results. We report two cases where the symptoms improved after switching from edoxaban to dabigatran. Our ndings suggest that changing DOAC may be effective in the treatment of refractory livedo vasculopathy. Future studies with more cases are necessary. Skin Research, 22 : 42-48, 2023