2023 Volume 22 Issue 2 Pages 104-108
A 42-year-old woman visited our department for a nodule on her left forearm that had been slowly increasing in size since one year before. Initial ndings revealed a 10 mm diameter, slightly keratinized, dome-shaped, elastic brown nodule. We performed total excision. The mass was spherical in shape and extended from the supercial to the deep dermis, with multiple multinucleated Touton and foreign-body giant cells, and foam cells, similar to those of xanthogranuloma. The deep dermis showed no giant cells, but rather proliferation of cells with spindle-shaped nuclei in a oral pattern. CD68 staining was positive in both areas ; however, in the shallow dermis just below the epidermis, the staining was almost circular, whereas in the deep dermis it was spindle-shaped. Factor XIIIa was clearly positive in the deep dermis ; however, it was attenuated in the shallow dermis areas where only foam-like cells were present. We hypothesized that dermatobroma and xanthogranuloma share a common origin. Skin Research, 22 :104-108, 2023
