A Case of Xanthogranuloma Comprised of Lymphoid Follicles

Abstract

We present the case of a 33-year-old female with xanthogranuloma comprised of lymphoid follicles. One year prior to her visit to our hospital, she noticed an induration on the right side of her chest. The induration gradually enlarged, and the patient experienced slight tenderness, prompting her to seek medical attention at our hospital. At the first visit to our hospital, a movable, elastic, hard subcutaneous induration approximately 2 cm in size was observed, accompanied by tenderness. Ultrasound and MRI examinations were performed, but a definitive diagnosis could not be made. We performed surgical excision of the induration. Histopathological examination revealed xanthogranuloma composed of lymphoid follicles without necrosis. Based on immunohistochemical findings, the lymphoid follicles were diagnosed as reactive. We hypothesized that the lymphoid follicles were caused by chronic inflammation. Xanthogranuloma comprised of lymphoid follicles without necrosis is rarely reported. We report our case and review the literature. Skin Research, 24: 9-13, 2025