Hifu no kagaku
Online ISSN : 1883-9614
Print ISSN : 1347-1813
ISSN-L : 1347-1813
CASE REPORT
Treatment of Intractable Prurigo with Roxithromycin : Report of Three Cases
Hoshiko Okano, Makiko Okunaka, Hideki Shimada, Ryoko Mori, Akihiko Ikoma, Naotomo Kambe, Youichi Nishimura, Yumi Matsumura, Eiko Toichi, Satoshi Kore-eda, Kenzo Takahashi, Takao Tachibana, Yoshiki Miyachi
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Keywords: Macrolide, Roxithromycin, Prurigo, Pruritus
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2004 Volume 3 Issue 2 Pages 156-160

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Abstract
Three patients with intractable prurigo were treated with roxithromycin (RXM), a 14-member macrolide, for intensely pruritic skin lesions. The pruritus had decreased promptly after initiation of therapy, followed by improvement of the eruptions. Although the mechanism of action of RXM in prurigo remains unclear, 14-member macrolides have been used for several pruritic skin diseases.
The improvement of pruritus may possibly be attributed to the numerous immunomodulatory and anti-inflammatory properties of 14-member macrolides. RXM and other 14-member macrolides can be useful in the treatment of prurigo and other pruritic skin diseases.
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© 2004 Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association
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