Abstract
Hyperkeratosis lenticularis perstans(HLP) is a rare disorder of keratinization , which is characterized by asymptomatic hyperkeratotic papules predominantly located on the lower extremities. The lesions are usually resistant to any treatment. In this paper, we report the effect of topical calcipotriol ointment on a case of HLP.
A 78 year-old man presented multiple, solitary, reddish-brown, hyperkeratotic papules on his dorsa of the feet and lower parts of the legs. The palms and soles were not involved. The lesions had persisted for 45 years and were almost asymptomatic. After removal of the hyperkeratotic papule, a pinpoint bleeding was observed. The patient did not report the occurrence of similar skin lesions in his family members. Data of laboratory examination were within normal limits.
Histologically, the epidermis at the center of the lesion was coverd with a focally hyperkeratotic horny layer. A dense, bandlike lymphocytic infiltrate was observed below the epidermis. Small number of extravasated erythrocytes were seen in the papillary dermis.
The patient was treated with twice daily application of topical calcipotriol ointment. The lesions gradually disappered after 3 months of treatment. The histopathological findings were normalized after the treatment of topical calcipotriol ointment.
