Papuloerythroderma(Ofuji) Successfly Treated with Oral PUVA Therapy

Abstract

A 67-year-old man had been suffering from pruritic eruption on the legs from May, 2001. Skin changes gradually worsened even though the patient had been treated with topical and systemic corticosteroids, and developed into erythroderma. Clinical findings were characterized by papules and plaques with cobblestone appearance on the body and limbs sparing large folds on the chest and abdominal regions. Broadband-UVB phototherapy was not effective and systemic corticosteroid had been continuously administered. Oral PUVA therapy was started with 30mg of 8 methoxypsoralen and 3~4J/cm² of UVA. Pruritus was sufficiently decreased after 2~3 treatments, and the eruptions disappeared almost completely after 10 exposures, then systemic corticosteroid was discontinued. After 20 treatments, PUVA therapy was switched to narrowband-UVB phototherapy to prevent the reccurence with beneficial effects.