2007 Volume 6 Issue 6 Pages 649-652
The first study was designed to compare the effects on melasma between 5% tranexamic acid ceream and 0.5% tranexamic acid cream by means of double-blind inter-group comparison. The percentage of cases where treatment was rated as slightly useful or better was over 70% in both the 5% tranexamic acid cream group and the 0.5% tranexamic acid cream group. The second study was designed to evaluate the effects on melasma of 5% tranexamic acid cream in comparison to drug-free ream base by means of double blind inter-group comparison. The percentage of cases where treatment was rated as slightly useful of better did not differ markedly between the 5% tranexamic acid cream group(54%) and the drug-free cream group(48%). In stratified analylis(analysis by the severity of melasma), however, the percentage of cases with sever melasma showing alleviation in respose to treatment was 85.7% in the 5% tranexami acid cream group(n=7) and 30.0% in the drug-free cream base group(n=10), and this difference was statistically significant(U test).