Abstract
A 65-year-old woman was diagnosed with polycythemia vera in February 1994, and treatment with hydroxyurea(HU)was started in 1996. She noticed an ulcer on the left lateral aspect of the ankle about 1 month before the initial examination. She treated the ulcer herself, but the ulcer became worse and she visited our department. In the initial examination, a painful cutaneous ulcer of 35×13mm in size was found on the left lateral aspect of the ankle. She had a past history of cutaneous ulcer on the right lateral aspect of the ankle that had occurred twice. It was diagnosed as HU-induced cutaneous ulcer from clinical findings, past histories and clinical course. Discontinuation of HU therapy and external application resulted in complete epithelization of the ulcer in about three months.
