Abstract
A 85-year-old man with prostate cancer had been receiving subcutaneous injections of Leuprolin acetate depot 3.75mg (for one month use) on his upper arms since May 2000. He noticed subcutaneous nodules on the injection sites after he changed the depot to 11.25mg (for three month use) in November 2002. The subcutaneous nodules were resected and histopathological examination showed foreign body granuloma. We diagnosed these nodules as foreign body granuloma caused by subcutaneous injections of Leuprorelin acetate.