Abstract
We describe a 35-year-old man with a metastasized malignant melanoma with the markedly elevated serum level of Granulocyte Colony-Stimulating Factor(G-CSF)and paraneoplastic leukemoid reaction. The patient suffered from a metastasised melanoma to the liver on two years after the total removal of primary lesion on his back. The patient’s white blood cell count exceeded 110,000/μl and the serum level of G-CSF was elevated up to 710pg/μl. The bone marrow infiltration contained markedly atypical cells, having clear cytoplasm and demonstrating positivity to anti-G-CSF antibody on immunohistochemical examination.
