Abstract
We report two Japanese patients with Stevens-Johnson syndrome (SJS) who were investigated for HLA gene markers associated with SJS and toxic epidermal necrolysis. Patient 1 was a 53-year-old woman. She developed eruptions in oral provocation tests and was diagnosed with SJS due to allopurinol, clarithromycin, and loxoprofen sodium. Gene analysis revealed HLA-B∗5801. Patient 2 was a 54-year-old man. He was positive on a carbamazepine patch test and drug-induced lymphocyte stimulation test, and was diagnosed with SJS due to carbamazepine. HLA-B∗1502 was not detected on gene analysis.
