Abstract
Case 1 : A 59-year-old man had been suffering from itching eruption on the axilla and inguinal areas 7 months before visiting our hospital. Itching eruptions gradually worsened even though the patient had been treated at another hospital. Clinical findings were characterized by brown indurative papules and nodules on the axilla, inguen, navel and nipple. A biopsy specimen revealed infiltration of atypical lymphocytes in the dermis around blood vessels and appendages, which were CD30-positive. Molecular analysis did not show monoclonal rearrangement of the TCR and HTLV-1 antibody was negative. We therefore diagnosed lymphomatoid papulosis. Oral PUVA therapy was started with 4J/cm2 UVA, and the eruptions disappeared almost completely after 14 exposures. Case 2 : A 38-year-old woman had had self-resolving, recullent eruptions on the right arm since 14 years of age. The eruptions had worsened from 20 years of age and she had been diagnosed with lymphomatoid papulosis by skin biopsy at another hospital 1 year before visiting our hospital. Oral PUVA therapy was started with 3-4J/cm2 UVA, and the eruptions disappeared almost completely after 3J/cm2×8 and 4J/cm2×20 exposures. Oral PUVA therapy is recommended for the treatment of lymphomatoid papulosis when other therapies are not effective.
