Abstract
A 54-year-old Japanese male patient with thymoma had been treated with prednisolone and tacrolimus (Prograf®) since 2004 for symptoms of myasthenia gravis. He eventually showed weakness in his cervical muscles as well as dyspnea, and was hospitalized in the Neurology ward in 2006. One month later, an eruption consisting of small erythema multiforme-like lesions appeared on his trunk, with swelling and fiushing of the face. He was referred to the Dermatology department where he was diagnosed as having a drug eruption. All medications other than prednisolone and tacrolimus were discontinued, yet the eruption spread accompanied by oral and conjunctival involvements, developing into Stevens-Johnson syndrome (SJS). Steroid pulse therapy and high dose immunoglobulin therapy was administered without response. However, the eruption quickly faded after discontinuing tacrolimus. We concluded that SJS was induced by tacrolimus (Prograf®) in a patient with immunoabnormality due to thymoma.
