Abstract
At a gynecological clinic, a 64-year-old female was prescribed Holin®-V vaginal tablet for atrophic colpitis. Within a few minutes after inserting the tablet into her vagina, she felt sick and erythematous macules developed over her whole body, and then angioedema of the throat, clouding of consciousness developed 30 minutes later. The symptoms disappeared immediately after washing of the vagina and injection of intravenous methylprednisolone. Prick testing for ingredients of Holin®-V vaginal tablet showed a positive reaction for macrogol 6000 and negative reactions for estriol and stearic acid magnesium. Based on these results, we diagnosed this patient as having anaphylaxis due to macrogol 6000.
