Abstract
We studied the clinical effect of FAD (flavin adenine dinucleotide) by measuring the activity of erythrocyte glutathion reductase (EGR) in 10 patients of seborrheic dermatitis. During treatment with steroid for external application alone, EGR activity was 4.64+1.02 U/gHb and FAD effect was 1.19+0.10. However, two weeks after the oral administration of 30mg FAD, these were 5.97+1.65 U/gHb and 0.98+0.07 respectively. FAD effect decreased significantly (p<0.01). There were three cases in which improvement of patients' conditions by additional administration of FAD was seen, and it was accompanied by increase of EGR activity and decrease of FAD effect in these cases.
