Abstract
The patient was a 67-year-old man. Erythematous pruritic eruptions developed in his abdomen and both lower extremities for 2 months ago. The skin lesions gradually extended and became to the condition of erythroderma with lymphadenopathy. Histological examination of the skin lesion revealed infiltration of atypical lymphocytes in the upper dermis with epidermotropism. Atypical cells with a indented cerebriform nucleus were recognized in the peripheral blood smears, and diagnosis of Sezary syndrome was made. He was treated with combination chemotherapy using cyclophosphamide, doxorubicin, vincristine, prednisolone and etoposide. After the 3rd. course of chemotherapy, the skin lesions improved and atypical cells in the periphral blood decreased. However, he died with interstitial pneumonia 5 months after development of the eruption appeared. Skin Research, 42: 352-55, 2000
