Abstract
The secretion of sebaceous gland has been said to be regulated by its innervation in cooperation with mm. arrectores pilorum (m. a. p.), or with mitoses of the gland cells. The author's report deals with morphological studies on human sebaceous glands in different ages and regions of the body using silver impregnation.
1) The nuclei of sebaceous gland cells showed vacuolization and atrophy towards infundibular part.
2) Net formations of the protoplasma disappeared gradually towards ductal part, indicating the holocrine nature of the sebaceous secretion .
3) Only 50% of sebaceous glands were connected with m. a. p..
4) Extremely delicate, centrifugal nerve fibers with fine net-works were found to touch at wall-cells and connective tissue sheeth of the distal one-third of the sebaceous gland. Rarely, centripetal nerve fibers as viscero-sensory nervous elements were observed.
5) Three types of nervous endformations were observed at the wall-cell layer and the connective tissue layer of the sebaceous gland. Inter- or intra-cellular innervation were absent.
6) These nerve fibers als oconnected in three different types with centrifugal nerve fibers of capillaries and of m. a. p. in the vicinity of the sebaceous gland.
These findings suggested that vegetative endformations belonged to the adrenergic nervous system of trophoneurotic nature, which was comparative with apocrine gland nervous elements. Discussions were given on various neuropathologic changes. Hypertrophic factors of sebaceous gland in puberty were considered due to the excited trophoneurotic and adrenergic vegetative endformations around sebaceous glands.
