Trousseau syndrome accompanied by cholangiocellular carcinoma: Report of two

Abstract

 Two cases of Trousseau syndrome associated with cholangiocellular carcinoma have been reported. The first patient, a 82-year-old woman, received chemotheraphy with weekly gemcitabine after the placement of a self-expanding metal stent for palliation of unresectable malignant biliary obstruction. She was admitted to our hospital because of dizziness in October 2010. A computed tomography (CT) showed fresh cerebral infarcts in the area of left middle cerebral artery and in the right temporal lobe. The final diagnosis was Trousseau syndrome accompanied by cholangiocellular carcinoma. She died 36 days after admission. The second patient, a 69-year-old woman, was admitted to our hospital because of disturbed consciousness. Her CT showed a cerebral infarct in the right temporal lobe. An enhanced abdominal CT showed a malignant tumor in left hepatic lobe. A fine needle biopsy showed a cholangiocellular carcinoma. The final diagnosis was Trousseau syndrome accompanied by cholangiocellular carcinoma. She died 25 days after admission.