Abstract
Although moderate intensity aerobic exercise (MIAE) is known to improve physical function and quality of life in patients with hematological malignancies, the effects on T cells and NK cells have not been fully studied. We sought to clarify the effects of MIAE on T cells and NK cells of patients with hematological malignancies in sterile rooms. We measured the population of T cells and NK cells at two points before and after MIAE in patients and healthy controls and evaluated physical activity using a triaxial accelerometer. In both groups, we observed a significant decrease in the CD4/8 ratio and CD4+/CD8－ cells as % of total lymphocytes as well as increased CD4－/8+ cells after MIAE. In the patient group, % CD56+/CD16+ cells did not change between pre- and post-MIAE, although the percentage of CD4+/CD25+/Foxp3+ cells and the CD4+ fraction significantly decreased, unlike the control group. Patients with low physical activity were particularly associated with a decrease in the percentage of CD4+/CD25+/Foxp3+ cells after MIAE. Our data suggest that MIAE may not be an optimal physical therapy for frail patients with low physical activity. However, further investigations are required to clarify the mechanisms by which MIAE alters T cells and NK cells in patients with hematological malignancies. Furthermore, we also need to examine whether MIAE affects their clinical outcomes.
