Modeling Approach to Estimate Site-Specific Intakes of DEHP via Agricultural and Livestock Products

Abstract

Following the agreement reached at the World Summit on Sustainable Development, risk-based chemicals management is now introduced worldwide. However, there are very little data available for human health risk assessment in many cases. In this paper, we examined a mathematical modeling approach to estimating site-specific intakes of Di(2-ethylhexyl) phthalate (DEHP) via agricultural and livestock products, including uncertainty analysis of model estimates. Although the estimated intakes agreed with the measured values in same order of magnitude, further works such as development of concentration correction factors and analysis on distribution channels will be required in order to apply this approach to site-specific exposure assessment of other hydrophobic chemicals via oral route.