Abstract
In 2015, the Consumers Affairs Agency asked preparation of a systematic review in its introduction of functional foods labelling in the new Food Labelling Law. Although a guideline for systematic review preparation was released by the agency, the basic concepts of the systematic review is not clearly written in the guideline. In the same year, OHAT (Office of Health Assessment and Translation) of NTP (National Toxicology Program) published a handbook which describes principles and the process of developing a systematic review. Regulatory science which should have a strong basis on systematic reviews must stand on the totality of scientific evidence, however it must be reliable and feasible with regard to application of its output to actual decision making. Referring to the basic requirements for the regulatory science as the basis in the decision making process and practice, current applications of regulatory science, especially in the field of food safety were considered.
