Abstract
penicillin was administered to healthy persons and patients parenterally, and the concomitant levels of penicillin in the blood serum and in the saliva were measured at various intervals after administration. Further the experiments were made on the inflluence of various drugs upon the excretion of penicillin.
1) Excretion of penicillin in saliva was observed by its administration over a sertain unit.
2) When 20000-30000 units of penicillin were administered, its excretion in saliva was observed in all cases of patients (2 cases of actinomycosis, 2 cases of acute alveolar abscess, 1 case after operation of ankylosis of madibular joint) but not observed in all cases of healthy persons.
3) The concentration of penicillin in saliva was always lower than that in blood.
4) Excretion of penicillin insaliva was influenced by injection of 1% pilocarpine (0.5cc), atropine (0.5cc), 0.1% adrenalin (0.5cc), acethylcholin (0.5cc), tetraethylammonium bromide (0.5cc), 0.1% histamin (1cc), 10% peptone (1cc), 50% invert sugar (1cc) and 10% saline solution (1cc). Eventually excretion of penicillin in saliva was disturbed by those drugs except pilocarpine, histamin and peptone.
