Immunological study of Sjögren's syndrome

No.3 anti cytomegalovirus neutralizing antibody in the sera

Abstract

The titers of and cytomegalovirus (CMV) neutralizing antibodies in the sera were measured on 27 patients who were diagnosed Sjiigren's syndrome (SjS), definite in 13 patients and probable in 14.
The results were as follows:
1) Anti CMV antibodies were found in the sera of 100% of the definite SjS patients, 97.6% of the probable SjS patients and 88.2% of normal middle-aged females.
2) The mean titers of and CMV neutralizing antibodies were 2^4.8 of definite SjS, 2^4.64 of probable SjS, 2^4.25 of steroid treated patients and 24.8 of normal females.
3) The distribution of and CMV neutralizing antibody titers of definite SjS patients was demonstrated from 2² to 2⁸. In contrast, that of normal females was demonstrated from 2³ to 2⁶.
4) Remarkably high antibody titers were noted in the sera of 3 SjS patients. This report suggests some possibilities that CMV infection relates to SjS.
This report suggests some possibilities that CMV infection relates to SjS.