Studies on Antitumor Activty of Propionibacterium acnes strain KT-28

Part 3: Histological Study Using Monoclonal Antibodies, Analysis of Lymphocyte Subset Infiltrated into Mouse Tumor Tissue Exposed to Enzyme Treated Cell Wall of Propinibacterium acnes

Abstract

Antitumor activity of Propionibacterium acnes strain KT-28, an isolate from the oral cavity, was examined by using mice inoculated with meth A cells. Histochemically, it was found that L3T4⁺ and Lyt2⁺ T cells invaded the tumor region of mice injected with the protease-treated ultrasonic sediment preparation. And macrophage and NK cells also invaded the tumor region of mice injected with the protease-treated ultrasonic sediment preparation. Furthermore, it was suggested that the antitumor activity might be related to the immune system.