Plasma Cell Granuloma of the Oral Cavity

Abstract

A 61-year-old female was referred to our Oral and Maxillofacial Surgery Department for evaluation of swelling of the gingiva adjacent to the left lower first molar. Since microscopic examination revealed a dense aggregate of plasma cells, myeloma was suspected. However, after thorough investigation, final diagnosis as a plasma cell granuloma could be made.
Microscopically, the plasma cells showed no cytologic abnormality and were accompanied by other inflammatory cells. Russel bodies were seen. In addition, the immunoperoxidase technique showed polyclonal population of plasma cells.
Treatment consisted of total resection of the lesion including the alveolar bone. No signs of recurrence have appeared 9 years postoperatively.