口腔粘膜疾患および舌痛症に対するセファランチン®内服療法の臨床的効果の検討

佐木 宏吉; 市原 秀記; 加藤 幸弘; 安藤 恵; 阿部 一雄; K.K.S. WIN; 井上 孝典; 藤塚 秀樹; 兵東 巌; 杉山 貴敏; 奥田 孝; 奥村 康明; 半田 祐二朗; 奥富 直; 立松 憲親; 岡 伸光

doi:10.11277/stomatology1952.43.84

Evaluation of Clinical Efficiency of Cepharanthin^® for the Treatment of Oral Mucosal Lesions and Glossodynia

Hiroyoshi SAKI, Hideki ICHIHARA, Yukihiro KATO, Megumi ANDO, Kazuo ABE, K.K.S. WIN, Takanori INOUE, Hideki FUJITSUKA, Iwao HYODO, Takatoshi SUGIYAMA, Takashi OKUDA, Yasuaki OKUMURA, Yujiro HANDA, Tadashi OKUTOMI, Norichika TATEMATSU, Nobumitsu OKA

Author information

Hiroyoshi SAKI
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine
Hideki ICHIHARA
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine
Yukihiro KATO
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine
Megumi ANDO
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine
Kazuo ABE
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine
K.K.S. WIN
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine
Takanori INOUE
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine
Hideki FUJITSUKA
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine
Iwao HYODO
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine
Takatoshi SUGIYAMA
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine
Takashi OKUDA
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine
Yasuaki OKUMURA
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine
Yujiro HANDA
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine
Tadashi OKUTOMI
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine
Norichika TATEMATSU
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine
Nobumitsu OKA
Department of Oral and Mexillofacial Surgery, Gifu University School of Medicine

Keywords: Cepharanthin^®, Oral lichen planus, Aphthous stomatitis, Leukoplakia, Glossodynia

JOURNAL FREE ACCESS

1994 Volume 43 Issue 1 Pages 84-89

DOI https://doi.org/10.11277/stomatology1952.43.84

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Abstract

This clinical study was carried out to evaluate the effectiveness of Cepharanthin^®, which is one of the biscoclaurine alkaloids, in the treatment of oral mucosal lesions (oral lichen planus, aphthous stomatitis, leukoplakia, glossodynia).
Cepharanthin^® has recently been applied in the treatment of many acute and chronic diseases, e. g. snakebite, leukopenia during radiation therapy or anticancer treatment, bronchial asthma, and alopecia areata.
Evaluation was conducted by an open trial after oral administration of 20 mg Cepharanthin^®per day.The clinical response was graded according to the assessment of pain, degree of erosion, extent of striae, degree of ulcer, and degree of erythema.
Overall improvement and safety rate was 87.0% in orallichen planus, 83.3% in aphthous stomatitis, 80.0% in leukoplakia, and 77.8% in grossodynia.
It might be due to the fact that no side effect detected in the cases presented in this study.

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