1994 Volume 43 Issue 3 Pages 363-368
We investigated the effects of collagen matrix on bone healing in the rabbit mandible. The collagen matrix was composed of the fibrillar collagen and the heat denatured collagen with the dehydrothermal cross-linking. This material was frozen at -30°C and freeze-dried to make a sponge-like structure.
The sponge collagen was grafted into the mandibular bone defects of the rabbits. Histological studies were performed in one, two and three weeks after grafting.
The sponge collagen structure promoted the infiltration of fibroblasts and newly formed capillary contrasted to the control defects. Also the bone formation in the collagen applied group was observed faster than the control group.
As a result, this collagen matrix promoted the reconstruction process of the mandibular bone defects.
