1996 Volume 45 Issue 1 Pages 67-71
The purpose of this paper was to clarify the evaluation of nutritional estimation during induction chemotherapy of oral cancer. Twenty-four untreated patients with oral squamous cell carcinoma, who received induction chemotherapy with PEP, VCR, MMC and CDDP in our department, were analyzed. For estimation of the nutritional status, the prognostic nutritional index (PNI) proposed by Onodera was used and this index was calculated by the following formula.
PNI = 0.005 × Lymphocyte count +10 × serum albumin (g/l)
There was no significant difference between the PNI value of effective cases and that of ineffective cases before chemotherapy. In all cases, the PNI value decreased during chemotherapy, but the value of effective cases was slightly higher than that of ineffective cases throughout the therapy. The rate of decrease in effective cases was lower than that in ineffective cases, and 4 of 6 cases, which showed increase of PNI during 1 course of chemotherapy, were effective cases. According to these results, it was surmised that there is a relationship between the PNI and the effect of induction chemotherapy.
