Urinary findings after tonsillectomy and tonsillar provocation test in IgA nephropathy

Abstract

We studied the urinary findings of 98 patients with IgA nephropathy after tonsillectomy. During one week after operation, a transient worsening of urinary findings were observed in 56% patients. Aggravation of hematuria was the most frequent finding. The aggravation of urinary abnormalities was temporary, and most of the patients showed the aggravation on the second post-operative day. The serial changes in the number of red blood cells and macrophages in the urine were examined in five patients, and corrected by the concentration of creatinine in the urine. The increase peaked from the second to the fourth day after the operation. Flow cytometry revealed that the increase in CD16-positive macrophages in the urine and CD16-positive monocytes in the blood corresponded to the time of aggravation by the urinary findings. CD16-positive monocytes in the blood were also increased on the second day after tonsillar provocation test. There is a possibility that the number of CD16-positive monocytes in the blood on the second day after tonsillar irradiation is a good indicator of the effects of the provocation test on IgA nephropathy.