Differentiated diagnoses of malignant lymphoma originated from the head and neck: By HE, immunostain and gene analyses

Abstract

In the present studies, we examined the biopsied materials of malignant lymphoma originating from the head and neck regions using histological analyses of HE, immunostain B and Tcells, and gene analysis of immunogloblin light and heavy chain, T cell receptor β, γ chains by Southern blot.
Finally, we diagnosed the five malignant lymphomas of seven cases.
Gene analyses seemed to have a lower rate of correct diagnosis than histological diagnosis in this study. However, this included the possibility of rapid detection of the first gene rearrangement without the detection of histlogical change of malignant lymphoma.
In the diagnosis of malignant lymphoma, it was necessary that we critically diagnosed in not only these studies but also other laboratory data and the clinical course.