Abstract
A 51-year-old man was admitted to our hospital for treatment of advanced pancreatic carcinoma. During surgery, several small liver metastases were discovered, and intraoperative electron beam irradiation (20 Gy) was performed for the main tumor with microwave coagulation carried out for the metastatatic sites. Postoperatively, the patient received gemcitabine 800 mg as a 10 mg/m2/min infusion followed by oxaliplatin 100 mg as a 1-hour infusion every 2 weeks. As the incidence of neurosensory disorders such as paresthesia of the lip or extremities increased with the number of courses administered, the gemcitabine-oxaliplatin regimen (GemOx) had to be stopped after ten courses. Neither nephrotoxicity nor hematologic toxicity was observed. The outpatient GemOx regimen was well tolerated by the patient. We believe that this case report demonstrates both the potential efficacy and side effects of GemOx for treatment of pancreatic carcinoma.
