Abstract
The Patient was a 51-year-old woman with diabetes mellitus. Abdominal ultrasonography revealed two hypoechoic lesions in the pancreas body and tail. CT showed low density areas without enhancement. Serum hormones (insulin, gastrin, glucagon) were within normal limits. Based on a diagnosis of multiple non-functioning endocrine tumors or solid-pseudopapillary tumors without cystic degeneration, spleen preserving distal pancreatectomy was performed. Histopathologically, neoplastic cells with small nuclei were arranged in a trabecular form with hyaline degeneration. Both Grimelius argyrophil reaction and chromogranin A reaction were positive. The tumors were diagnosed histopathologically as non-functioning endocrine tumors with hyaline degeneration. There was also marked hyaline degeneration of most of the islet cells in the non-tumor region the pancreas.
