Disorder of coagulation-fibrinolysis system in patients with severe acute pancreatitis

Abstract

A disorder of the coagulation-fibrinolysis system was investigated retrospectively in patients with severe acute pancreatitis (SAP). On admission, the rates of coagulation-fibrinolysis factors were aberrantly high, especially those of Thrombin-antithrombin III complex (TAT) and D-dimer were 100%. Prothrombin-international normalized ratio (PT-INR) and TAT had significantly positive correlation with the Japanese severity score, and the platelet count had a significantly negative correlation. TAT concentration on admission was higher in patients of Stages 3&4;. Compared with survivors, PT-INR was significantly higher, and TAT tended to be higher in non-survivors. In patients with PT-INR ≥ 1.15 or TAT ≥ 45ng/ml on admission, the mortality rate was significantly higher. These results suggest that TAT may be a useful marker for the assessment of severity and prognosis in SAP.