A case of drug-induced hemolytic uremic syndrome during adjuvant chemotherapy with gemcitabine hydrochloride after resection of pancreatic cancer

Abstract

A 70-year-old man presented with a chief complaint of abdominal pain and was diagnosed with resectable pancreatic cancer. Adjuvant chemotherapy with gemcitabine hydrochloride was started after a partial pancreatic resection and D2 dissection. On day 1 of his fifth course of therapy, his serum creatinine was 2.05mg/dl, his urine tested positive for protein, and bilateral kidney enlargement was found on abdominal computed tomography. Gemcitabine hydrochloride was stopped. The condition was diagnosed as a drug-induced renal disorder and hemolytic uremic syndrome after kidney biopsy. Serum creatinine levels fell after treatment with prednisolone, and no relapse of pancreatic cancer has occurred 13 months after the administration of prednisolone.