Pancreatic endocrine tumor with complete obstruction of the main pancreatic duct: Report of two cases

Abstract

Pancreatic endocrine tumors(PETs) rarely show complete obstruction of the main pancreatic duct(MPD) compared with pancreatic ductal carcinoma on endoscopic retrograde pancreatography(ERP). We herein report 2 cases of PETs with complete MPD obstruction. The first case is a male in his 40's who was referred to our hospital for further examination of a pancreatic tumor. The other case involves a male in his 40's who visited us for the scrutiny of the MPD dilatation. On ERP, complete MPD obstruction was seen in both cases. The final diagnosis was well-differentiated endocrine carcinoma and well-differentiated endocrine tumor (uncertain behavior), respectively. Moreover, contrast-enhanced endoscopic ultrasonography(CE-EUS) presented atypical poor enhanced images in both cases. We thought the complete MPD obstruction on ERP and unusual images on CE-EUS might be important factors for predicting the malignant potential in PETs.