Efficacy and indication of continuous regional arterial infusion of a protease inhibitor and an antibiotic in the treatment of severe acute pancreatitis

Abstract

A large amount of experimental and clinical data providing evidence on the usefulness of continuous regional arterial infusion (CRAI) therapy for severe acute pancreatitis (SAP), including a randomized controlled trial, have been collected since 1996. CRAI therapy, in the early phase of SAP, can reduce the incidence of pancreatic infectious complications and mortality rate in patients with acute necrotizing pancreatitis. CRAI therapy can be applied for patients with SAP in whom contrast-enhanced computed tomography (CECT) shows pancreatic ischemia and/or necrosis in the early stage of SAP.