Abstract
A number of clinical observational studies providing evidence for the efficacy of continuous regional arterial infusion (CRAI) therapy for severe acute pancreatitis (SAP), including a randomized controlled trial have been collected since 1996. On the other hand, a recent clinical study (propensity score matching analysis) using DPC data showed no significant difference between CRAI group and non-CRAI group in mortality rate and incidence of intervention. The Revision Committee of the Japanese Guidelines for the management of acute pancreatitis downgraded the recommendation for CRAI therapy because efficacy of CRAI for severe acute pancreatitis has not been confirmed.
