Abstract
Recently, long non-coding RNAs (lncRNAs), which are defined as non-coding RNAs (ncRNA) of more than 200 nucleotides in length, are being increasingly revealed to contribute to various biological processes in several diseases including cancer via diverse mechanisms. It has been reported that some lncRNAs can be transferred by extracellular vesicle (EV) from donor cells to recipient cells, and modulate cell signaling and behaviors in the recipient cells. Although the roles of EV lncRNAs on carcinogenesis or the development of pancreatic cancer were not well understood, several lncRNAs have been associated with playing important regulatory roles in epithelial-mesenchymal transition (EMT), which regulates invasion and metastasis in pancreatic cancer. Therefore, to investigate the roles of lncRNA and the mechanisms of lncRNA transfer by EV, would provide several useful insights to improve the clinical applications for diagnosis and therapy in human pancreatic cancer.
