Japanese Familial Pancreatic Cancer Registry with the aim to early detection of pancreatic cancer

Abstract

Familial pancreatic cancer (FPC) is defined as kindred in whom at least a pair of first-degree relatives have been diagnosed with pancreatic cancer. Members of FPC kindred have an increased risk of developing pancreatic cancer. The National Familial Pancreas Tumors Registry (NFPTR) at Johns Hopkins Hospital is the first and largest registry in the world and was established in 1994, and this project has produced robust results. The Japan Pancreas Society established the Japanese Familial Pancreatic Cancer Registry (JFPCR) in 2014. This project is expected to identify causative cancer genes, and improve new strategies for the screening and treatment of Japanese pancreatic cancer patients. Especially, the improved screening for pancreatic cancer is a most desirable objective. The JFPCR provides a system of periodic follow up of individuals that are at high risk of developing pancreatic cancer and serves as valuable platform for developing and testing new interventions for the screening and early detection of pancreatic cancer.