Preservation of pancreatic endocrine and exocrine function of patients who underwent pancreatic resection

Abstract

We report the results of pancreatic endocrine and exocrine function of patients who underwent pancreatic resection and discuss the preservation of pancreatic endocrine and exocrine function after pancreatic resection. Pancreatic endocrine and exocrine insufficiency occurred in 41.0% and 65.5% of patients who underwent pancreatoduodenectomy and 30.8% and 26.4% of patients who underwent distal pancreatectomy, respectively. Remnant pancreatic volume after pancreatic resection was the only independent risk factor of pancreatic endocrine insufficiency as well as pancreatic exocrine insufficiency. Stenosis or obstruction of pancreaticoenteric anastomosis induces postoperative atrophy of remnant pancreas. Reliable pancreaticoenteric anastomosis is important to prevent postoperative pancreatic endocrine and exocrine insufficiency. Moreover, adequate administration of pancreatic enzyme supplements or insulin is mandatory for patients who develop postoperative pancreatic endocrine and exocrine insufficiency after pancreatic resection.