Special Editions
Changing concepts of pancreatic neuroendocrine neoplasms: From WHO 2010 to WHO 2017
2019 Volume 34 Issue 2 Pages 56-62
Details
2019 Volume 34 Issue 2 Pages 56-62
The WHO 2010 classification has been widely employed to classify gastro-enteric-pancreatic neoplasms because of its close correlation with clinicopathological parameters of patients including clinical outcomes. However, since its publication, some problems have been raised regarding its three tier classification, NET or neuroendocrine tumor G1, G2 and G3. Based on these issues, a novel classification of pancreatic neuroendocrine neoplasms was proposed as WHO 2017. In this review, an outline of this new WHO 2017 classification will be reviewed with emphasis upon the differentiation between NET and NEC (neuroendocrine carcinoma) and the standardization of Ki67 labeling index.
