2023 Volume 38 Issue 1 Pages 2-9
The pancreas is a solid organs with a three-dimensional (3D) cellular structure, where cell-to-cell interactions could play key roles in organ development, homeostasis and regeneration as well as diseases including tumorigenesis. To understand the mechanisms underlying those processes, it is important to investigate signaling pathways not only within cells but also between cells.
Recent advances in experimental techniques including a 3D culture system, Cre/loxP-based genetic lineage tracing and cell ablation models, have allowed us to explore cell-to-cell communications, leading to an improved understanding of tissue behaviors as a cell population. We present recent reeslts to provide a brief overview of intercellular crosstalk in the pancreas.
