Antimicrobial Property of Titanium Plates Treated with Silica-Bound Protamine

Abstract

Antimicrobial activity is necessary for dental prosthetic devices to maintain oral and systemic health in elderly people wearing prostheses. In particular, dental prosthetic devices with antifungal properties are urgently needed to prevent aspiration pneumonia. However, practical application methods to deliver antimicrobial properties to dental prosthetic devices have not yet been established. Therefore, in this study we aimed to fix protamine on titanium plates treated with silica coating using a Silano-Pen, and to evaluate the antimicrobial properties of the titanium plates against Candida albicans. Strong antifungal properties were obtained by soaking titanium plates in an aqueous protamine solution after silica coating treatment. Since this brand-new method is simple, its practical application is expected in the near future.