The Showa University Journal of Medical Sciences
Online ISSN : 2185-0968
Print ISSN : 0915-6380
ISSN-L : 0915-6380
Immunohistochemical Detection of Aromatase in Breast Carcinomas
Yuko TSUNODAKentaroh KAMIYAAkira TSUNODATerumasa SAWADAMitsuo KUSANOYukiko SHIMIZUTakumi YANAIHARAMasafumi TAKIMOTOHidekazu OHTA
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2000 Volume 12 Issue 3 Pages 247-252

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Abstract
The immunohistochemical detection of aromatase was performed in breast carcinoma specimens obtained from 55 patients. Thirty-nine carcinomas were from postmenopausal women and 16 from premenopausal women. Aromatase immunoreactivity was observed in 33 of 55 cases (60%) . The positivity for aromatase staining was 64% in the postmenopausal group and 50% in the premenopausal group. The postmenopausal group tended to have a significant positive association between estrogen receptor expression and aromatase positivity (p=0.035) . The immunohistochemical detection of aromatase expression may be useful in the monitoring of postoperative endocrine therapy in women with breast carcinoma.
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© The Showa Medical Association
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