Abstract
We studied the effects of the kampo medicines, sho-saiko-to (SST), oren-gedoku-to (OGT), sanmotsu-ogon-to (SOT), keigai-rengyo-to (KRT), senkyu-chacho-san (SCS), on rat hepatic drug-metabolizing enzymesin vivo. Hot-water extracts of each kampo medicine were given orally at doses of 100 and 1000 mg/kg. After a single administration, SST increased activities of aniline hydroxylase (ANH), aminopyrineN-demethylase (APD), and cytochrome c reductase (cyt. c red.) and levels of cytochromeP-450 (P-450) and cytochrome b5 (b5) in the liver. Single administrations of OGT, SOT, and SCS decreased activities of ANH and APD and P-450 content and increased cyt. c red. activity. A single administration of KRT at 100 mg/kg increased ANH and APD activities, but at a dose of 1000 mg/kg decreased both activities. Repeated administration of test drugs at doses of 100 and 1000 mg/kg/day for 14 days resulted in the following: SST and OGT reduced ANH activity; SCS and KRT reduced APD activity; OGT and KRT loweredP-450 content; cyt, c. red. activity was increased by SST, OGT, and SOT and was reduced by KRT. These results suggest that the examined kampo medicines may modify the effectiveness of simultaneously administered drugs that are metabolized by hepatic enzymes.
