1982 Volume 17 Issue 2 Pages 77-88
Three groups of female mice (Jcl: ICR) were raised in the exposure chambers set atthe roadside in Osaka City. One group was exposed to ambient air, and the other one to filtered ambient air (dust free), and the control group to purified air. The results obtained by hematological and histopathological examinations during exposure for two years were as follows.
The findings observed only in the ambient air group were, the appearance of free large dust cells in the bronchial and alveolar cavity, the deposition of black dusts in the lung tissue, and sometimes foreign body polynuclear cells and a small number of granulomatous change of the lung.
The findings observed common to the ambient air and the filtered air groups were the increase of goblet cells in nasal mucosa, the proliferation of tracheal mucous glands, the hyperplasia of bronchiolar epithelium, edematous thickening of alveolar wall, and minimal signs of red blood cell anemia.
Any significant differences were not found among body weight change and half survival time of three groups.
The mean levels of ambient air pollutants during the experimental period at the exposure site were, also presented in parenthesis the percentage of inside-chamber pollutants to ambient air, 97.6 μg/m3 (68%) of suspended particulate matter, 18 ppb (100%) of sulfur dioxide, 51 ppb (77%) of nitrogen dioxide, 0.2 ppm (82%) of nitrogen monoxide, and 8.4 ppm (93%) of carbon monoxide.
