1983 Volume 18 Issue 5 Pages 444-452
The toxicological effects of photochemical oxidant mixtures (Ox) and Ozone (O3) on Jet: ICR female mice were compared. The animals were exposed to Ox (peak concentration: 0.8-1.4 ppm), O3 simulated to Oxpattern and O3 at 3 ppm in constant concentration for 3 hours. Ox was generated by UV-irradiation in the smog chamber containing diluted automobile exhaust gas, nitric oxide and propylene. Immediately after the exposure, rectal temperature, blood pH, erythrocyte acetylchotinesterase and 2, 3-diphosphoglycerate (2, 3-DPG), serum cholinesterase (ChE), GPT, total bilirubin, total cholesterol, urea nitrogen and alkaline-phosphatase (ALP, basic and Mg activated types) and erythrocyte osmotic fragility were measured.
Ox was more effective than O3 with simulated pattern of Ox on the changes of 2, 3-DPG, Mg activated type ALP, ChE and erythrocyte osmotic fragility, but less effective on urea nitrogen and total cholesterol. The effects of Ox and 03 on body temperature were in opposition. These results indicated that the toxicological effects of Ox could not be explained by O3 alone.
We reported previously that leucocyte count, leuco-index and erythrocyte count increased in the mice exposed to Ox in accordance with clinical findings of the seriously suffered patients during the smog episodes. In the present report, arise of body temperature and the increase of ChE activity in animals exposed to Ox were also similar with the findings in the episodes. However, the facts that all of the clinical findings were not the same with those in animals exposed to Ox generated in the smog chamber suggested the presence of the other hazardous substances in real photochemical smog.
