Effects of Pyrene or Benzo (a) pyrene on the Mutagenicity of Trinitrochlorobenzene or Tetranitrocarbazole

Sumiom GOTO; Akihiro KAWAI; Yukihiko TAKAGI; Osamu ENDO; Motohide MURATA; Hidetsuru MATSUSHITA

doi:10.11298/taiki1978.19.318

Sumiom GOTO, Akihiro KAWAI, Yukihiko TAKAGI, Osamu ENDO, Motohide MURATA, Hidetsuru MATSUSHITA

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Keywords: Nitro aromatic compound, Polynuclear aromatic hydrocarbon, Mutagenicity, Salmonella typhimurium TA98, Charge transfer complex

JOURNAL FREE ACCESS

1984 Volume 19 Issue 4 Pages 318-320

DOI https://doi.org/10.11298/taiki1978.19.318

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Abstract

Effects of polynuclear aromatic hydrocarbons on the mutagenic activity of nitro aromatic compounds were investigated by the pre-incubation method using Salmonella typhimurium strain TA98 without S-9 mix.
Pyrene gave an enhancing effect for the mutagenicity of trinitrochlorobenzene. On the other hand, pyrene or BaP gave inhibitory effects for the mutagenicity of tetramitrocarbazole. Formation of charge-transfer complex was suggested for one of reason of these effects.

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