Comparison between Carcinogenicity of N-Nitrosodiethylamine and Benzo (a) pyrene in the Respiratory Organs of Syrian Golden Hamsters when Induced by Intratracheal Instillation

Abstract

A comparison between the carcinogenicity of N-Nitrosodiethylamine (NDEA) and of benzo (a) pyrene [B (a) P] was carried out using male Syrian golden hamsters which were administered a total dose of 7.5 mg by means of intratracheal instillation once a week for 15 weeks. At the same time, a control group of hamsters were treated with a phosphate buffer solution. During their total life span, tumor incidence rates of the respiratory organs in the NDEA and B (a) P groups were 100% and 69% respectively, while in the control group it was 8%. With these results, it can be concluded that the carcinogenic potency of NDEA in the respiratory organs of Syrian golden hamsters is much higher than that of B (a) P.